Spiderman brand New Day will have multiple villains like Scorpion, Tarantula, Boomerang and The Hand.  Spiderman will struggle with not felling like himself, while trying to keep Peters life separate from Spiderman, and connecting with Ned and Mj as peter.

In Spiderman Brand New Day, Sadie Sink has her own role, apparently she will be Jean Gray, a mutant superhero that will help Spiderman or Sadie Sink is an alternat version of Gwen. Venom might even be in Spiderman Brand New Day, which brings even more questioning of Peter not feeling like he is Peter Parker anymore. Spiderman might have to fight Hulk (aka Bruce Banner) in Spiderman Brand New Day.

He will even reach out to Bruce Banner (aka Hulk) to help him with the transition of his spider powers. His spider powers are starting to be able to make his own spider webs, making him more variable as his spider powers evolve to the second stage of a spiders life, out of three stages.